Recent updates of iodinated contrast media hypersensitivity

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Allergic Immediate Hypersensitivity to Iodinated Contrast Media

Background: Immediate hypersensitivity reactions (IHR) to iodinated contrast media (ICM) have traditionally been considered nonallergic; however, the increasingly frequent reporting of positive skin test and basophil activation test results suggests a specifi c allergic mechanism in some patients. Skin tests have been proposed as a useful tool for diagnosis, although their sensitivity and predi...

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Management of hypersensitivity reactions to iodinated contrast media.

All iodinated contrast media (CM) are known to cause both immediate ( £ 1 h) and nonimmediate (>1 h) hypersensitivity reactions. Although for most immediate reactions an allergic hypersensitivity cannot be demonstrated, recent studies indicate that the severe immediate reactions may be IgE-mediated, while most of the nonimmediate exanthematous skin reactions, appear to be T-cell mediated. Patie...

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The Potential Utility of Iodinated Contrast Media (ICM) Skin Testing in Patients with ICM Hypersensitivity

Both immediate and delayed hypersensitivity reactions to iodinated contrast media (ICM) are relatively common. However, there are few data to determine the clinical utility of immunologic evaluation of ICM. To evaluate the utility of ICM skin testing in patients with ICM hypersensitivity, 23 patients (17 immediate and 6 delayed reactions) were enrolled from 3 university hospitals in Korea. With...

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Examination of patients suspected as having hypersensitivity to iodinated contrast media with leukocyte migration test.

In vivo tests may be used for the diagnosis of allergy to iodinated contrast media (ICM); however, the tests do not provide definitive diagnosis and are associated with risks for patients. Diagnoses based on in vitro tests are limited, and there are almost no relevant studies. Herein, the authors examined involvement of allergic reaction from a multilateral standpoint in 39 patients suspected o...

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Severe hypersensitivity reactions to iodinated contrast media: clinical and immunological features in a cohort of patients

Background Iodinated contrast media (ICM) are diagnostic agents used in millions of X-ray procedures yearly. Although current agents are usually well tolerated, mild immediate hypersensitivity reactions (IHR) occur in about 0.15% to 3% of administrations and severe IHRs in 0.01% to 0.04%. Despite this low incidence these reactions are an important clinical problem because the increasingly large...

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ژورنال

عنوان ژورنال: Allergy, Asthma & Respiratory Disease

سال: 2020

ISSN: 2288-0402,2288-0410

DOI: 10.4168/aard.2020.8.3.107